Large cell culture surface.
Small footprint.
Tired of dealing with many single vessels for your adherent cell culture? Our compact system optimizes the use of cleanroom footprint. Designed for maximum productivity in minimal space.
Your benefits with the CellScrew®
Maximize space: Get more out of your cleanroom with a compact, high-output system. Increase your production capacity without intensively expanding your infrastructure.
Minimized process adjustments: Seamless scaling without the need for costly and time-consuming re-optimization.
Consistent results: Comparable surface conditions in all sizes lead to reproducible outcomes across various scale-up stages.
Same growth surface area
CellScrew® mini (850 cm²) compared to a standard T75-flask (75 cm²)
The genius in the bottle
The innovative internal structure based on an Archimedes' screw, concentric cylinders and a central tube, forms a large growth surface on a small footprint and fosters optimal growth conditions with low shear forces and excellent gas exchange. See how to inoculate, cultivate and harvest cells in the CellScrew® in our introduction video.
Archimedes' screws:
excellent mixing and consistent medium supply under low shear forces
Central tube: constant flow of the liquids and liquid handling using a serological pipette
Concentric cyclinders:
form a large surface area on a small footprint
Resource-conscious cell cultivation
Laboratories are among the most resource-intensive facilities, consuming up to 10 times more energy than office buildings and accounting for up to 60% of carbon emissions in research institutions.⁴
The CellScrew® not only conserves your resources but also those of our planet. Through material-efficient additive manufacturing and the use of plant-based materials, the CellScrew® boasts a 90% lower carbon footprint than other adherent cell cultivation systems.
CellScrew®
Common systems
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Can all adherent cell lines be cultivated in the CellScrew®?The CellScrew® has been tested with various cell lines, such as mouse fibroblasts (L-929), human kidney cells (HEK-293), and stem cells (human mesenchymal stromal cells). The adhesion rates, growth rates, and final cell densities observed were comparable to or better than those achieved on standard polystyrene surfaces. For more information on the testing of HEK-293 cells on the PLA surface and the CellScrew®, please refer to this Application Note.
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Does the CellScrew® have a smaller carbon footprint compared to standard cell culture devices?Yes! The CellScrew® is made from polylactic acid (PLA), which is derived from the polymerization of lactic acid produced from plants. Our additive manufacturing process allows us to produce the same growth surface area with up to 80% less material compared to injection molded culture systems. To comprehensively assess the carbon footprint of the CellScrew®, we are currently conducting a life cycle analysis.
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Can cells be visualized under the microscope in the CellScrew®?The CellScrew® cannot be microscoped, similar to most other expansion systems that exceed a growth surface of ~300 cm². However, we are currently developing a fully automated, closed production platform for the cellScrew. This platform will allow you to monitor and control all crucial cultivation parameters to create a controlled and reproducible process.
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Do I need to buy additional equipment to use the CellScrew®?The CellScrew® is handled just as a regular roller bottle, where it is placed in an incubator on a roller device. However, it is crucial to position the roller bottle at a 10-15 degree angle on the roller to ensure the filter cap remains dry and the system operates effectively. For simultaneous cultivation of three CellScrew® mini in the dimensions of a CellScrew® 6K, the first order of our bundle includes the CellScrew®mini TriDock.
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Is the CellScrew® sterile?Yes, the CellScrew® comes fully sterilized, as it is vacuum sealed and gamma irradiated. We strongly advise against autoclaving the CellScrew® as it can cause damage to the product's structure and integrity.