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Adherent cell expansion effortlessly scaled.
Boost efficiency,
reduce costs.

Our innovative cell culture system simplifies the scaling process, cutting down on time and resources for biopharma production.

Your benefits with the CellScrew®

Minimized process adjustments: Seamless scaling without the need for costly and time-consuming re-optimization.

Consistent results: Comparable surface conditions in all sizes lead to reproducible outcomes across various scale-up stages.

Maximize space: Get more out of your cleanroom with a compact, high-output system.

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Easy transition from lab to production scale

Thanks to the CellScrew®s large surface area and small volume, available in three sizes from 850 cm² to 10,000 cm², you can easily scale your cell expansion without complex process adjustments.

Excellent growth conditions

Constant and homogeneous supply with oxygen and nutrients facilitate cell growth while limiting unwanted cell differentiation. Our Application Notes provide detailed information on the culture conditions and suitability of our system for cultivating adherent cells.

Comparison matrix of adherent cell cultivation systems: with good mixing and a large growth area the CellScrew has advantages over roller bottles, T-flasks and multi-tray stack systems

Same growth surface area

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CellScrew® mini (850 cm²) compared to a standard T75-flask (75 cm²)

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Large surface area,
small footprint

One CellScrew®'s surface area combines the area of several standard cultivation systems, such as roller bottles and T-flasks. See a comparison of surface areas and advantages featured in the CellScrew®.

The genius in the bottle

The innovative internal structure based on an Archimedes' screw, concentric cylinders and a central tube, forms a large growth surface on a small footprint and fosters optimal growth conditions with low shear forces and excellent gas exchange. See how to inoculate, cultivate and harvest cells in the CellScrew® in our introduction video.



 

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Archimedes' screws:
excellent mixing and consistent medium supply under low shear forces

Central tube: constant flow of the liquids and liquid handling using a serological pipette

Concentric cyclinders:
form a large surface area on a small footprint

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Start cultivating with our starter special.

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Order our CellScrew® mini bundle and receive the TriDock cultivation adapter with your first purchase

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Receive detailed onboarding from our Sales team

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Get expert support from our R&D team

Resource-conscious cell cultivation

Laboratories are among the most resource-intensive facilities, consuming up to 10 times more energy than office buildings and accounting for up to 60% of carbon emissions in research institutions.⁴

The CellScrew® not only conserves your resources but also those of our planet. Through material-efficient additive manufacturing and the use of plant-based materials, the CellScrew® boasts a 90% lower carbon footprint than other adherent cell cultivation systems. 

Learn more about PLA as growth surface

CellScrew®

Common systems

  • Can all adherent cell lines be cultivated in the CellScrew®?
    The CellScrew® is TC-treated and has been tested with various cell lines, such as mouse fibroblasts (L-929), human kidney cells (HEK-293), and stem cells (human mesenchymal stromal cells). The adhesion rates, growth rates, and final cell densities observed were comparable to or better than those achieved on standard polystyrene surfaces. For more information on testing HEK-293 cells on the PLA surface and the CellScrew®, please refer to this Application Note.
  • Can cells be visualized under the microscope in the CellScrew®?
    The CellScrew® cannot be microscoped, similar to most other expansion systems that exceed a growth surface of ~300 cm².
  • Do I need to buy additional equipment to use the CellScrew®?
    The CellScrew® is handled just as a regular roller bottle, where it is placed in an incubator on a roller device. However, it is crucial to position the roller bottle at a 10-15 degree angle on the roller to ensure the filter cap remains dry and the system operates effectively. For simultaneous cultivation of three CellScrew® mini in the dimensions of a CellScrew® 6K, the first order of our bundle includes the CellScrew®mini TriDock. Find more instructions on the set-up of the CellScrew® on our Handling page and in our CellScrew® Expert Series.
  • Is the CellScrew® sterile?
    Yes, the CellScrew® comes fully sterilized, as it is gamma irradiated. We strongly advise against autoclaving the CellScrew® as it can cause damage to the product's structure and integrity.
  • Can the CellScrew® be used with coating?
    Yes, the CellScrew® works with all standard coatings for adherent cells, including those used for cultivation of stem cells such as iPSCs or MSCs.
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