Boost your cell output and reduce cost
The CellScrew® saves you long processing times, expensive reagents, and limited lab space - with a large growth area in a compact vessel.
Filled with medium, the CellScrew®10K weighs only
2.1 kg
Time efficient handling
Even with its large growth surface, the CellScrew® can be conveniently held in one hand. As it saves you manual handling steps, the CellScrew® gives you and your colleagues in the lab more time for other important tasks.
More space in the incubator
One CellScrew® 10K can replace twelve standard roller bottles, freeing up valuable incubator space.
Same growth surface area
CellScrew® 10K compared to a standard roller bottle
(850 cm²)
Harvest your cells in one batch and reduce trypsin by up to
66 %
Reduce cultivation reagents
Tests with HEK-293 cells showed harvest efficiencies in the CellScrew® of over 90% - with 66% less trypsin.
Potential to automate
The CellScrew® is the foundation for automated adherent cell cultivation.
We are currently developing a fully automated platform that integrates the CellScrew® and allows you to monitor and control all critical cultivation parameters of your cell culture in real time.
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Can all adherent cell lines be cultivated in the CellScrew®?The CellScrew® has been tested with various cell lines, such as mouse fibroblasts (L-929), human kidney cells (HEK-293), and stem cells (human mesenchymal stromal cells). The adhesion rates, growth rates, and final cell densities observed were comparable to or better than those achieved on standard polystyrene surfaces. For more information on the testing of HEK-293 cells on the PLA surface and the CellScrew®, please refer to this Application Note.
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Does the CellScrew® have a smaller carbon footprint compared to standard cell culture devices?Yes! The CellScrew® is made from polylactic acid (PLA), which is derived from the polymerization of lactic acid produced from plants. Our additive manufacturing process allows us to produce the same growth surface area with up to 80% less material compared to injection molded culture systems. To comprehensively assess the carbon footprint of the CellScrew®, we are currently conducting a life cycle analysis.
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Can cells be visualized under the microscope in the CellScrew®?The CellScrew® cannot be microscoped, similar to most other expansion systems that exceed a growth surface of ~300 cm². However, we are currently developing a fully automated, closed production platform for the cellScrew. This platform will allow you to monitor and control all crucial cultivation parameters to create a controlled and reproducible process.
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Do I need to buy additional equipment to use the CellScrew®?The CellScrew® is handled just as a regular roller bottle, where it is placed in an incubator on a roller device. However, it is crucial to position the roller bottle at a 10-15 degree angle on the roller to ensure the filter cap remains dry and the system operates effectively. For simultaneous cultivation of three CellScrew® mini in the dimensions of a CellScrew® 6K, the first order of our bundle includes the CellScrew®mini TriDock.
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Is the CellScrew® sterile?Yes, the CellScrew® comes fully sterilized, as it is vacuum sealed and gamma irradiated. We strongly advise against autoclaving the CellScrew® as it can cause damage to the product's structure and integrity.