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Discover the latest insights, industry trends, and expert perspectives. From breakthrough innovations to behind-the-scenes stories, our articles keep you informed and inspired—because great ideas deserve a spotlight!
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GMP compliance in Cell Therapy & AAV manufacturing
Good Manufacturing Practice (GMP) is the foundation of quality assurance in biopharmaceutical manufacturing. It ensures that therapeutic products, including cell therapies and viral vectors like Adeno-Associated Virus (AAV), are produced under strict quality control to meet safety, purity, and efficacy standards.
Joel
Jun 45 min read
13 views


Adherent and suspension cell culture
In cell culture, two primary growth methods exist: adherent culture and suspension culture. The choice between these methods depends on cell type, application, and scalability needs. While adherent cells require attachment to a surface for growth, suspension cells freely float in liquid media. Each approach has its unique advantages, limitations, and specific cultivation requirements.
Mira
May 284 min read
22 views


Why the scale-up of cell culture is essential for manufacturing Cell and Gene therapies
The successful commercialization of cell and gene therapies (CGTs) depends on the ability to scale production efficiently while maintaining product consistency, safety, and regulatory compliance. A well-designed bioreactor scale-up strategy is critical in ensuring that processes developed in early-stage research can transition seamlessly into commercial-scale biomanufacturing.
Mira
May 263 min read
12 views


Investing in European bioreactors: A convergence of scientific impact and market growth
The life science tools sector, particularly bioreactor technologies, is emerging as a high-growth investment frontier in Europe, combining scientific innovation with robust market dynamics. Driven by pandemic-era acceleration and sustained demand for biopharmaceuticals, this sector offers compelling opportunities for venture capital (VC) and institutional investors. Here's why bioreactors and related technologies are poised to deliver strong returns while advancing global hea
Felix
May 223 min read
9 views


The relevance of the oxygen transfer rate for successful cell cultivation
In the development and manufacture of advanced biopharmaceuticals—including cell and gene therapies—cell expansion is a critical step that directly influences yield, quality, and consistency of the final product. Maintaining a viable and productive cell population requires precise control over multiple parameters within the bioreactor environment. Among these, dissolved oxygen (DO) concentration in the liquid phase stands out as a critical process parameter (CPP).
Lukas
May 203 min read
26 views


Bioreactors - function, application, and challenges
Bioreactors are essential tools in biotechnology, enabling controlled environments for cell culture, fermentation, and metabolite production. Their role is crucial in biopharmaceutical manufacturing, regenerative medicine, and large-scale cell expansion. As bioprocessing demands grow, bioreactor scale-up becomes a key challenge, ensuring that laboratory-developed processes translate effectively into industrial-scale production.
Mira
May 164 min read
38 views


Scale-up vs. scale-out in bioprocessing
Scalability is a fundamental challenge in bioprocessing, particularly in cell culture-based manufacturing. As the demand for advanced therapeutics, including cell and gene therapies, continues to grow, manufacturers must choose between two primary strategies for increasing production capacity: scale-up and scale-out.
Joel
May 144 min read
32 views


2D vs 3D cell culture: What’s best for scalable biopharmaceutical production?
Cell culture systems are the foundation of modern biopharmaceutical production, playing a crucial role in advanced therapy medicinal products (ATMPs), viral vector manufacturing, and cell-based therapies. The decision between 2D and 3D cell culture impacts scalability, process robustness, and final product quality, making it essential for manufacturers to select the right approach.
Joel
May 94 min read
37 views


Why Germany is falling behind in Cell and Gene Therapeutics (CGT) and how we can turn it around
In recent years, Germany’s role in biotech has evolved, particularly in cell and gene therapy manufacturing, where its strong GMP expertise is both an asset and a challenge. While Germany remains a key hub for innovation, complex bureaucracy, extensive documentation requirements, and rigid GMP standards have made scaling advanced therapies slow and costly.
Felix
May 63 min read
32 views


The base of curing for many diseases: Cell and Gene Therapy Manufacturing
Cell and Gene Therapies (CGT) represent a groundbreaking advancement in modern medicine, offering curative potential for genetic disorders, cancer, and degenerative diseases. These therapies utilize engineered cells or genetic modifications to treat or replace damaged tissues and defective genes. All approaches demand highly controlled manufacturing processes to ensure safety, efficacy, and scalability.
Mira
Apr 285 min read
26 views


Autologous vs allogenic cell therapy: key differences and applications
Advanced therapies like cell-based therapies have emerged as a promising field in regenerative medicine, offering novel treatment approaches for conditions such as cancer, autoimmune diseases, and degenerative disorders. One critical distinction in these therapies is whether the cells come from the patient themselves (autologous) or from a donor (allogeneic). Both approaches have unique benefits and limitations, impacting their clinical application and scalability.
Katharina
Apr 255 min read
48 views


Mandatory sustainability: How the Green Deal and Global Regulations are reshaping biotech
Sustainability has long been considered a "nice-to-have" in biotech and pharma - but this is changing fast. With the advent of binding regulations like the European Green Deal and its global counterparts, sustainability is moving from corporate responsibility to legal obligation.
Mira
Apr 168 min read
22 views


Well plates: sizes, variants and their application in the lab
Well plates are essential lab tools, available in various sizes and treatments for research, screenings, and cell culture applications.
Annika
Apr 74 min read
37 views


iPSC and MSCs: Transforming Regenerative Medicine
iPSCs and MSCs are transforming regenerative medicine by curing diseases once considered untreatable.
Katharina
Apr 35 min read
27 views


What are iPSCs and MSCs and how are stem cells cultivated?
Stem cell cultivation of iPSCs and MSCs is essential to ensure scalability for regenerative medicine and advanced therapies.
Katharina
Mar 314 min read
15 views


Working together for a sustainable future: Bürkert Fluid Control Systems and Green Elephant Biotech
Working together for a sustainable future: Bürkert Fluid Control Systems and Green Elephant Biotech
Mira
Feb 134 min read
189 views


New addition to innovative CellScrew® product line: a down-scale model for adherent cell culture
Green Elephant adds a new member to CellScrew® series: CellScrew® mini as an entry-level solution for efficient, scalable cell culture
Mira
Jul 8, 20242 min read
143 views


Green Elephant Biotech expands sustainable 96-well plate line for light-sensitive experiments
Green Elephant Biotech is expanding its product line of plant-based 96-well plates with two new additions: black and white 96-well plates.
Mira
Apr 9, 20242 min read
95 views


The complex problem behind sustainability in the life and health sciences sector
4.4% of the global net emissions are produced by the healthcare sector. What does it need for the sector to become more sustainable?
Josephine Greenall-Ota, Mira Sternstein
Mar 27, 20249 min read
210 views


CellScrew® Expert Series
Welcome to this special blog post, a short video series, created to enhance your workflow and steer clear of potential pitfalls! Whether...
Carolin
Feb 6, 20242 min read
199 views

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