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CellScrew®

 
A solution for large-scale adherent cell expansion that efficiently utilizes your lab space, is easy to use, and reduces
carbon emissions by 90%.

 

CS10K

Cell culture area:       10,000 cm²
Media volume:           450 - 1,300 mL

CS6K

Cell culture area:       6,000 cm²
Media volume:           250 - 800 mL

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The CellScrew® enables you to ...

Improve your processes

Simplify handling

Reduce

cost

Increase sustainability

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Benefit from the CellScrew®s patented design.

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Reduce 90% CO₂ emissions with the CellScrew®.

How? It offers a much better material-to-surface ratio than conventional multi-tray stack systems and is manufactured from sustainable, plant-based polylactic acid (PLA).

PLA is made from corn starch and therefore has a significantly better CO₂ balance than fossil-based polystyrene.

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The CellScrew® is a greener solution for ...

Cell and Gene Therapy
Vaccine Manufacturing
Drug Screening and Development
Adherent Cell Expansion

Start cultivating efficiently and sustainably with our starter-bundle.

Order 3 CellScrew® 6K with a bundle discount

Receive detailed onboarding from our Sales team

Get expert support from our R&D team

Here is how it works

The CellScrew®s compact design makes it easy to handle and occupies minimal space in the lab, boosting your lab’s productivity. You can start using our system with just an incubator and a roller bottle device - no additional equipment required.

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  • Can all adherent cell lines be cultivated in the CellScrew®?
    The CellScrew® has been tested with various cell lines, such as mouse fibroblasts (L-929), human kidney cells (HEK-293), and stem cells (human mesenchymal stromal cells). The adhesion rates, growth rates, and final cell densities observed were comparable to or better than those achieved on standard polystyrene surfaces. For more information on the testing of HEK-293 cells on the PLA surface and the CellScrew®, please refer to this Application Note. Order free material sample 12-well plates to test our surface with your specific cell line.
  • Does the CellScrew® have a smaller carbon footprint compared to standard cell culture devices?
    Yes! The CellScrew® is made from polylactic acid (PLA), which is derived from the polymerization of lactic acid produced from plants. Our additive manufacturing process allows us to produce the same growth surface area with up to 80% less material compared to injection molded culture systems. To comprehensively assess the carbon footprint of the CellScrew®, we are currently conducting a life cycle analysis.
  • Is the CellScrew® GMP-certified?
    The CellScrew® is currently research grade, but we aim to achieve GMP compliance by the end of Q1 2024 and are in the process of constructing a GMP-compliant facility to support this goal.
  • Can cells be visualized under the microscope in the CellScrew®?
    The CellScrew® cannot be microscoped, similar to most other expansion systems that exceed a growth surface of ~300 cm². However, we are currently developing a fully automated, closed production platform for the cellScrew. This platform will allow you to monitor and control all crucial cultivation parameters to create a controlled and reproducible process.
  • Do I need to buy additional equipment to use the CellScrew®?
    The CellScrew® is handled just as a regular roller bottle, where it is placed in an incubator on a roller device. However, it is crucial to position the roller bottle at a 10-15 degree angle on the roller to ensure the filter cap remains dry and the system operates effectively.
  • Is the CellScrew® sterile?
    Yes, the CellScrew® comes fully sterilized, as it is vacuum sealed and gamma irradiated. We strongly advise against autoclaving the CellScrew® as it can cause damage to the product's structure and integrity.

Do you have questions or a request? We look forward to your message. 

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