top of page
CS10K with media

Cultivate green: Sustainable adherent cell culture

Signet plant-based

Cultivate adherent cells with 90% less CO₂ emission - in an innovative, material-efficient vessel made from plant-based plastic.

100% plant-based plastic

The CellScrew® is made of poly-lactic acid (PLA), a plant-based biopolymer produced entirely from renewable crops.The crops used for PLA synthesis remove CO₂ from the atmosphere, and emissions are returned to the earth during the disposal process.

Comparison matrix of adherent cell cultivation systems: with good mixing and a large growth area the CellScrew has advantages over roller bottles, T-flasks and multi-tray stack systems
Material-surface-ratio (g/cm²) of a CellScrew® 6K vs. multi-tray stack systems. The CellScrew® has a ratio of 0.1 g/cm², while the value of competing systems goes up to 0.6 g/cm².

Large output, less material

The CellScrew® provides the same cell culture surface area as conventional multi-tray stack systems, but requires significantly less material to manufacture. That means 80% less goes into your lab waste.

*The calculation provided is an estimate and is based on average data for conventional products available on the market. 

Reduce carbon emissions by 90%

Made from PLA, which is synthesized from renewable resources, and with an efficient material-to-growth area ratio, the CellScrew® allows you to expand your cells with 90% less CO₂ emissions than conventional systems.

Cross-section of a CellSrew®10K showing the internal structure of Archimedes' screws and cocentric cylinders

Inner values that count

The low material consumption is achieved by a delicate inner structure that is produced with a 3D printer. Consisting of Archimedes’ Screws and concentrically arranged cylinders, this structure also creates excellent cultivation conditions with excellent gas exchange and low shear forces.

Comparison matrix of adherent cell cultivation systems: with good mixing and a large growth area the CellScrew has advantages over roller bottles, T-flasks and multi-tray stack systems

The CellScrew® combines the benefits of conventional adherent cell culture systems. 

Start cultivating efficiently and sustainably with our starter-bundle.

Order 3 CellScrew® 6K with a bundle discount

Receive detailed onboarding from our Sales team

Get expert support from our R&D team

  • Can all adherent cell lines be cultivated in the CellScrew®?
    The CellScrew® has been tested with various cell lines, such as mouse fibroblasts (L-929), human kidney cells (HEK-293), and stem cells (human mesenchymal stromal cells). The adhesion rates, growth rates, and final cell densities observed were comparable to or better than those achieved on standard polystyrene surfaces. For more information on the testing of HEK-293 cells on the PLA surface and the CellScrew®, please refer to this Application Note. Order free material sample 12-well plates to test our surface with your specific cell line.
  • Does the CellScrew® have a smaller carbon footprint compared to standard cell culture devices?
    Yes! The CellScrew® is made from polylactic acid (PLA), which is derived from the polymerization of lactic acid produced from plants. Our additive manufacturing process allows us to produce the same growth surface area with up to 80% less material compared to injection molded culture systems. To comprehensively assess the carbon footprint of the CellScrew®, we are currently conducting a life cycle analysis.
  • Is the CellScrew® GMP-certified?
    The CellScrew® is currently research grade, but we aim to achieve GMP compliance by the end of Q1 2024 and are in the process of constructing a GMP-compliant facility to support this goal.
  • Can cells be visualized under the microscope in the CellScrew®?
    The CellScrew® cannot be microscoped, similar to most other expansion systems that exceed a growth surface of ~300 cm². However, we are currently developing a fully automated, closed production platform for the cellScrew. This platform will allow you to monitor and control all crucial cultivation parameters to create a controlled and reproducible process.
  • Do I need to buy additional equipment to use the CellScrew®?
    The CellScrew® is handled just as a regular roller bottle, where it is placed in an incubator on a roller device. However, it is crucial to position the roller bottle at a 10-15 degree angle on the roller to ensure the filter cap remains dry and the system operates effectively.
  • Is the CellScrew® sterile?
    Yes, the CellScrew® comes fully sterilized, as it is vacuum sealed and gamma irradiated. We strongly advise against autoclaving the CellScrew® as it can cause damage to the product's structure and integrity.
bottom of page