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CS10K with media

Adherent cell cultivation made easy

Simplify adherent cell cultivation in your lab.

Discover the CellScrew®s advantages for large-scale cell cultivation - say goodbye to bulky, heavy handling.

Less vessels -
less lab work

The CellScrew® offers a growth surface twelve times larger than that of a standard roller bottle while maintaining comparable external dimensions,

Operating one vessel instead of twelve not only reduces manual handling steps and lab space, but also decreases the risk of contamination.

Same growth surface area

12 Roller Bottles
CellScrew Icon

CellScrew® 10K compared to a standard roller bottle
(850 cm²)

Filled with medium,
the CellScrew® 6K weighs only

1.4 kg

while multi-tray stacks with the same growth surface weigh up to

4.4 kg

6,000 cm² in one hand

With the CellScrew®, you can hold 6,000 cm² of growth area filled with medium in just one hand. This allows for convenient handling by one person.

Excellent growth conditions

The CellScrew® combines the advantages of conventional cell culture systems: The internal structure creates a large growth surface area, provides excellent oxygenation, and facilitates low-shear mixing.

Comparison matrix of adherent cell cultivation systems: with good mixing and a large growth area the CellScrew has advantages over roller bottles, T-flasks and multi-tray stack systems

Here is how it works

Start cultivating efficiently and sustainably with our starter-bundle.

Icon three CellScrew®s

Order 3 CellScrew® 6K with a bundle discount

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Receive detailed onboarding from our Sales team

Icon Support: Question and Answer

Get expert support from our R&D team

  • Can all adherent cell lines be cultivated in the CellScrew®?
    The CellScrew® has been tested with various cell lines, such as mouse fibroblasts (L-929), human kidney cells (HEK-293), and stem cells (human mesenchymal stromal cells). The adhesion rates, growth rates, and final cell densities observed were comparable to or better than those achieved on standard polystyrene surfaces. For more information on the testing of HEK-293 cells on the PLA surface and the CellScrew®, please refer to this Application Note. Order free material sample 12-well plates to test our surface with your specific cell line.
  • Does the CellScrew® have a smaller carbon footprint compared to standard cell culture devices?
    Yes! The CellScrew® is made from polylactic acid (PLA), which is derived from the polymerization of lactic acid produced from plants. Our additive manufacturing process allows us to produce the same growth surface area with up to 80% less material compared to injection molded culture systems. To comprehensively assess the carbon footprint of the CellScrew®, we are currently conducting a life cycle analysis.
  • Is the CellScrew® GMP-certified?
    The CellScrew® is currently research grade, but we aim to achieve GMP compliance by the end of Q1 2024 and are in the process of constructing a GMP-compliant facility to support this goal.
  • Can cells be visualized under the microscope in the CellScrew®?
    The CellScrew® cannot be microscoped, similar to most other expansion systems that exceed a growth surface of ~300 cm². However, we are currently developing a fully automated, closed production platform for the cellScrew. This platform will allow you to monitor and control all crucial cultivation parameters to create a controlled and reproducible process.
  • Do I need to buy additional equipment to use the CellScrew®?
    The CellScrew® is handled just as a regular roller bottle, where it is placed in an incubator on a roller device. However, it is crucial to position the roller bottle at a 10-15 degree angle on the roller to ensure the filter cap remains dry and the system operates effectively.
  • Is the CellScrew® sterile?
    Yes, the CellScrew® comes fully sterilized, as it is vacuum sealed and gamma irradiated. We strongly advise against autoclaving the CellScrew® as it can cause damage to the product's structure and integrity.
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